Effects of continuous venovenous hemofiltration on cardiopulmonary function in a porcine model of endotoxin-induced shock
Murphey, E.D.; Fessler, J.F.; Bottoms, G.D.; Latshaw, H.; Johnson, M.; Mueller, B.; Clark, W.; Macias, W.
American Journal of Veterinary Research 58(4): 408-413
1997
ISSN/ISBN: 0002-9645 PMID: 9099389 Document Number: 472853
Objective-To determine whether continuous venovenous hemofiltration, proposed to remove inflammatory mediators from circulation, would resolve cardiopulmonary derangements in a model of established endotoxic shock. Animals-16 clinically normal pigs. Procedure-Endotoxin was infused, IV, into anesthetized pigs for a total of 50 minutes. Thirty minutes after termination of the infusion period, extracorporeal circulation was initiated through a 50-kd diafilter, or past the filter without ultrafiltrate formation. Cardiac and respiratory variables were monitored for a period of 4 hours. Results-Infusion of lipopolysaccharide resulted in a severe hypodynamic circulatory state, with significant decreases in mean arterial pressure and cardiac output concurrent with a significant increase in pulmonary arterial pressure. Hemofiltration was not associated with any correction of lipopolysaccharide-induced cardiopulmonary derangements. Conclusions-Continuous venovenous hemofiltration, as used in this acute experiment, did not improve cardiopulmonary dysfunction during endotoxic shock. Clinical Relevance-Continuous venovenous hemofiltration needs further investigation before it can be recommended as a clinically effective treatment.