New esters of Halopredone for topical antiinflammatory use
Toscano, L.; Grisanti, G.; Bianchetti, A.; Bossoni, G.
Arzneimittel-Forschung 27(9): 1634-1635
1977
ISSN/ISBN: 0004-4172 PMID: 579128 Document Number: 118126
A series of new halopredone esters has been prepared and screened for local and systemic antiinflammatory activity. High local activity with no side effects, equivalent to that of 17,21-bis(acetyloxy)-2-bromo-6beta,9-difluoro-11beta-hydroxypregna-1,4-diene-3,20-dione (halopredone acetate; Topicon), is obtained when either the 17- or 21-OH of halopredone are benzoylated.
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