Mutagenicity for Salmonella typhimurium of urine obtained from humans receiving nitrofurantoin
Wang, C.Y.; Benson, R.C.; Bryan, G.T.
Journal of the National Cancer Institute 58(4): 871-873
1977
ISSN/ISBN: 0027-8874 PMID: 321796 Document Number: 117087
Urine samples from 12 humans receiving oral therapeutic doses of nitrofurantoin for urinary infection were mutagenic for S. typhimurium strain TA 100 and nonmutagenic for strain TA 100-FR1. Mutagenic activity of the urine was not increased by treatment with .beta.-glucuronidase. Spot mutation assay of the chromatogram of urine revealed that the mutagenic activity of the urine was due to unmetabolized nitrofurantoin.
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