Incidence of drug-related deaths secondary to high-dose methotrexate and citrovorum factor administration
Von Hoff, D.D.; Penta, J.S.; Helman, L.J.; Slavik, M.
Cancer Treatment Reports 61(4): 745-748
1977
ISSN/ISBN: 0361-5960 PMID: 301783 Document Number: 116906
A review of 498 patients treated with high-dose methotrexate (MTX) with citrovorum factor rescue revealed 29 drug-related deaths. Until the important factors in those deaths are identified, the use of high-dose MTX should be limited to institutions that possess the necessary supportive facilities and the ability to measure serum levels of the drug.