Procedure for the determination of 4-hydroxy-3-methoxyphenylethyleneglycol in urine by gas chromatography with flame-ionization detector
Biondi, P.A.; Cagnasso, M.; Secchi, C.
Journal of Chromatography 143(5): 513-518
1977
ISSN/ISBN: 0021-9673 PMID: 893639 Document Number: 116664
Measurements of urinary 4-hydroxy-3-methoxyphenylethyleneglycol (HMPG) are of importance in clinical studies of psychiatric disorders and in the diagnosis of catecholamine-secreting tumors. Recent papers have reported elaborate methods for the determination of HMPG either by GLC with electron-capture detection (GC-ECD) or by mass fragmentography. A selective procedure for the routine determination of urinary HMPG by GC with a flame-ionization detector (GC-FID) was devised. This detector is more generally used than the ECD in clinical laboratories.