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Standardization of chemical cholerogen-toxoid cholera vaccine according to the content of somatic O-antigen

Sumarokov, A.A.; Dzhaperidze, M.N.; Ivanov, N.R.; Karaeva, L.T.; Popov, A.A.

Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 1977(4): 99-106

1977

ISSN/ISBN: 0372-9311
PMID: 405829
Document Number: 116421
The authors discuss the results of studies on the choice of highly-reproducible and sufficiently informative methods of 9-antigen standardization in a new chemical vaccine against cholera (cholerogen-toxoid); materials were collected under conditions of controlled epidemilogical trial. Titration of O-antigen in industrial batches of the preparation with the aid of precipitation in gel against standard O-cholera serum could be used for its standardization. Quantitative limits of O-antigen responsible for the formation of vibration (antimicrobial) antibodies in the persons vaccinated were found by studying the immunogenicity and reactogenicity of a number of cholerogen-toxoid batches contrast by O-antigen content described by means of the precipitation test.

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