Choleragen-anatoxin chemical cholera vaccine enriched with Ogawa O-antigen
Dzhaparidze, M.N.; Nikitina, G.P.; Kulikova, V.L.; Popov, A.A.; Naumov, A.V.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 4: 70-74
1984
ISSN/ISBN: 0372-9311 PMID: 6204471 Document Number: 225394
The cultural fluid of Vibrio cholerae strains of serovar Ogawa, grown under the conditions of submerged cultivation, has been shown to contain a large amount of soluble O-antigen which sharply differs from all other concomitant components in its molecular weight. By enriching the commercial chemical cholera vaccine known as Choleragen Toxoid with purified Ogawa O-antigen a new preparation, consisting mainly of cholera toxoid and Ogawa and Inaba O-antigens and capable of producing pronounced immunity to V. cholerae of both serovars, has been obtained.
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