Evaluation of the therapeutic and toxic action of platinum cis-dichlorodiamine
Fiserová, J.; Dostálová, O.; Drobnik, J.; Faistavr, J.; Holik, F.
Voprosy Onkologii 23(8): 68-74
1977
ISSN/ISBN: 0507-3758 PMID: 333750 Document Number: 114028
The substance under study was employed in 9 patients with a far-advanced lesion. Dosage of 7.5 mg/m2 of the body surface failed to render any effect, whereas 15 mg/m2 induced partial regression in 2 patients and stabilization of the process in another 2 patients. Some toxic phenomena were noted on the part of the digestive tract.
Document emailed within 1 workday
Related Documents
Kelland, L.R.; Abel, G.; McKeage, M.J.; Jones, M.; Goddard, P.M.; Valenti, M.; Murrer, B.A.; Harrap, K.R. 1993: Preclinical antitumor evaluation of bis-acetato-ammine-dichloro-cyclohexylamine platinum(IV): an orally active platinum drug Cancer Research 53(11): 2581-2586Dobrzańska-Tatarczuch, L.; Starek, A. 1991: Evaluation of combined toxic action of benzene and ethanol in the rat fetus Folia Medica Cracoviensia 32(3-4): 257-273
Czajkowska, T.; Krysiak, B.; Stetkiewicz, J. 1977: Comparative evaluation of acute and subacute toxic action of aniline and O-isopropoxyaniline Medycyna Pracy 28(3): 157-174
Tsagareli, G.A.; Kurtskhaliia, V.A.; Terterova, T.G.; Keburiia, K.L. 1973: Comparative evaluation of the therapeutic action of some antitrichomonal agents Vestnik Dermatologii i Venerologii 47(11): 52-56
Endo, K.; Akamatsu, K.; Matsumoto, T.; Morikawa, K.; Koizumi, M.; Mitsui, H.; Koizumi, K. 1992: Antitumor effects of three platinum complexes, (-)-(R)-2-aminomethylpyrrolidine(1,1-cyclobutanedicarboxylato)-platinum (II) monohydrate (DWA2114R), cis-diammine-(1,1-cyclobutanedicarboxylato)platinum(II) (CBDCA) and cis-diamminedichloroplatinum(II) (CDDP), in mice Anticancer Research 12(1): 49-58
Marokko, I.N.; Kulakova, S.N.; Krzhechkovskaia, V.V.; Ushakov, V.V.; Pestova, M.I.; Mazo, V.K.; Levachev, M.M. 1990: An experimental evaluation of the hypoallergenic action of fat constituents for specialized therapeutic products Voprosy Pitaniia 2: 49-53
Salmini, G.; Cione, R.; Oldrini, R. 1970: Clinical evaluation of the therapeutic action of a beta-blocking agent associated with a nitroderivative Minerva Cardioangiologica 18(5): 311-315
Sikorski, R.; Tynecka, Z.; Zrubek, H.; Radomański, T.; Ostasz, T. 1978: Clinical and microbiologic evaluation of the therapeutic action of colistin-Polfa in obstetrics and gynecology Materia Medica Polona. Polish Journal of Medicine and Pharmacy 10(3): 218-225
Schenone, H.; Prieto, R.; Angulo, M.; Galdames, M.; Romero, E.; Villarroel, F. 1980: An evaluation of the therapeutic action of tinidazole suppositories in intestinal infections by Protozoa in children Boletin Chileno de Parasitologia 35(1-2): 2-5
Pichugin, V.V.; Sumin, S.A.; Gatsura, V.V. 1980: Evaluation of the therapeutic action of hexosephosphate as an energy-supplying agent in acute coronary insufficiency Kardiologiia 20(5): 80-84
Dominici, C.; Petrucci, F.; Alimonti, A.; La Torre, F.; Cifani, A.; Caroli, S. 1995: Platinum-based antineoplastic agents: biomedical applications and therapeutic aspects Annali Dell'istituto Superiore di Sanita 31(2): 289-294
Kas'ianenko, N.A.; Aĭa, E.E.; Bogdanov, A.A.; Kosmotynskaia, I.V.; Iakovlev, K.I. 2002: Comparison of DNA complexation with antitumor therapeutic cis-DDP and binuclear bivalent platinum compound containing pyrazine Molekuliarnaia Biologiia 36(4): 745-752
Bruevich, T.S.; Bogomolets, N.N.; Berezovskiĭ, A.D. 1980: Sensitizing action of precious metal compounds: gold, platinum, ruthenium, rhodium and silver Gigiena Truda i Professional'nye Zabolevaniya (5): 42-44
Hausheer, F.H.; Kanter, P.; Cao, S.; Haridas, K.; Seetharamulu, P.; Reddy, D.; Petluru, P.; Zhao, M.; Murali, D.; Saxe, J.D.; Yao, S.; Martinez, N.; Zukowski, A.; Rustum, Y.M. 1998: Modulation of platinum-induced toxicities and therapeutic index: mechanistic insights and first- and second-generation protecting agents Seminars in Oncology 25(5): 584-599
Shalimov, S.A.; Keĭsevich, L.V.; Medvetskiĭ, E.B.; Tarasiuk, B.A.; Volchenskova, I.I. 1994: Antiviral action of the macromolecular derivative of the platinum with deoxyribonucleic acid in the treatment of patient with malignant liver neoplasm Klinicheskaia Khirurgiia 8: 36-38
Ota, K.; Oguma, T.; Shimamura, K. 1994: Pharmacokinetics of platinum in cancer patients following intravenous infusion of cis-diammine(glycolato)platinum, 254-S Anticancer Research 14(3b): 1383-1387
Winograd, B.; Vermorken, J.B.; ten Bokkel Huinink, W.W.; Simonetti, G.; Gall, H.E.; Knobf, M.K.; van der Vijgh, W.J.; McVie, J.G.; Pinedo, H.M. 1986: Phase i study of ethylenediamine platinum(II) malonate (NSC 146 068), a second generation platinum analogue Cancer Research 46(4 Part 2): 2148-2151
Linasmita, V.; Wilailak, S.; Srisupundit, S.; Tangtrakul, S.; Bullangpoti, S.; Israngura, N. 1998: Epithelial ovarian cancer treated by platinum or platinum analogue with cyclophosphamide: experience in Ramathibodi Hospital Journal of the Medical Association of Thailand 81(1): 10-16
Saegusa, Y.; Eriguchi, M.; Kidani, Y.; Matsuzawa, A.; Takeda, Y. 2001: Antitumor effects of a new lipophilic platinum compound, trans-bis(n-valerato)(1R,2R-cyclohexanediamine)(oxalato)platinum(IV), in mice Anticancer Research 21(1a): 245-252
Siddik, Z.H.; Thai, G.; Yoshida, M.; Zhang, Y.P.; Khokhar, A.R. 1994: Tetravalent platinum complexes with ammine/amine carrier ligand configuration: circumvention of platinum resistance in vivo Anti-Cancer Drug Design 9(6): 495-509