Effect of inhibitors of nucleic synthesis on induction of the secondary immunologic response in vitro
Pershin, S.B.; Maslova, T.N.; Kaulen, D.R.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 7: 34-38
1977
ISSN/ISBN: 0372-9311 PMID: 561500 Document Number: 113853
The authors studied the influence of the DNA and RNA inhibitors on the formation of antibody-forming cell populations in induction of a secondary immunological response in vitro. Low concentrations of cytosine-arabinoside, the DNA synthesis inhibitor, increased the count of indirect hemolysin-forming and rosette-forming cells; its high concentrations depressed the secondary immunological response induction in the direct hemolysin-forming cell system more intensively than in the indirect cell system. Actinomycin D depressed the stimulation of secondary immunological response in vitro both in the systems of direct and indirect hemolysin-forming, and of rosette-forming cells.