2 models of indomethacin-induced arterial hypertension in rats in chronic experiments
Sokolova, R.I.; Nekrasova, A.A.; Levitskaia, I.V.; Speranskaia, N.V.; Volkov, V.N.
Kardiologiia 17(10): 78-85
1977
ISSN/ISBN: 0022-9040 PMID: 202775 Document Number: 113772
Chronic administration of small doses of the prostaglandin [PG] synthesis inhibitor indomethacin against the background of a salt load or unilateral nephrectomy induces the development of arterial hypertension in rats. Arterial pressure increases (2 fold on the average) on the 6th wk of the experiment in 60-80% of the animals. Arterial hypertension developing against the background of a salt load is marked by retention of Na in the organism and increase in intravascular volume. Development of hypertension in unilateral nephrectomy is caused by increased Na excretion and reduced intravascular volume. Depressed activity of the renin-angiotensin-aldosterone system and conspicuous changes in the renal vascular channel are noted in both forms of arterial hypertension. Apparently, disorders in the metabolism of cyclic nucleotides underlie the changes occurring in the renal vessels due to the effect of indomethacin. Similar generalized changes in the peripheral vascular channel may increase vascular resistance and because of hypertension development.