Chronic administration of serotonin transporter inhibitor (fluoxetine) decreases monocrotaline-induced pulmonary hypertension in rats
Kozhevnikova, V.V.; Medvedeva, N.A.
Eksperimental'naia i Klinicheskaia Farmakologiia 70(5): 15-18
2007
ISSN/ISBN: 0869-2092 PMID: 18074800 Document Number: 608713
The effect of a chronic fluoxetine treatment on the development of monocrotaline-induced pulmonary hypertension has been studied in rats. It was found that fluoxetine decreased right ventricular hypertrophy and reduces pulmonary vessels thickness. These results suggest that chronic fluoxetine treatment can lead to a decrease in the manifestation of pulmonary hypertension symptoms.
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