Studies on demyelination by activated lymphocytes in the rabbit eye. II. Antibody-dependent cell-mediated demyelination
Brosnan, C.F.; Stoner, G.L.; Bloom, B.R.; Wisniewski, H.M.
Journal of Immunology 118(6): 2103-2110
1977
ISSN/ISBN: 0022-1767 PMID: 325140 Document Number: 113221
The rabbit eye model was used to investigate the role of antibody to CNS antigens in effecting primary demyelination. Serum from rabbits immunized with homologous spinal cord in complete Freund's adjuvant G, and the adsorbed IgG, upon elution, retained the activity. It was relatively stable to heating at 56.degree. C for 30 min. Light microscopic examination indicated that the primary demyelination occurred in the vicinity of the invading cells, and EM suggested an active stripping of myelin by these cells. These results establish an antibody-dependent cell-mediated mechanism for primary demyelination.