Bone lesions in Gaucher's disease
Moore, M.; Coley, B.L.
Journal of the Tennessee State Medical Association. Tennessee State Medical Association 40(4): 101-106
1947
ISSN/ISBN: 0735-7338 PMID: 20293054 Document Number: 11207
This disease was first described as an entity by P. C. E. Gaucher in his "These de Paris" in 1882 who called it a primary epithelioma. This impression has been progressively altered so that we now conceive of the condition as being an as yet imperfectly understood derangement of lipoid metabolism. In this the lipoid kerasin may infiltrate the entire reticulo-endothelial system so that the spleen, liver, bone marrow, and lymph nodes may each or all be affected. Bone involvement was first described by Brill and Mandelbaum in 1904.3 Kerasin contains nitrogen, but no phosphorous, and is chemically inactive. It cannot be stained by any of the usual lipoid stains. Only Mallory's blue connective tissue stain brings out the wrinkles in the protoplasm of the Gaucher cell. In bone, as in other tissues, the pathognomonic Gaucher cell is demonstrated and occurs in one or all of the following patterns: (a) scattered diffusely; (b) in poorly outlined and confluent areas; (c) in small localized collections.
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