Chemotherapy of advanced L1210 leukemia with platinum compounds in combination with other antitumor agents
Gale, G.R.; Atkins, L.M.; Meischen, S.J.; Smith, A.B.; Walker, E.M.
Cancer Treatment Reports 61(3): 445-450
1977
ISSN/ISBN: 0361-5960 PMID: 872142 Document Number: 111673
Six antitumor platinum compounds were used in combination with cyclophosphamide (CY) plus one of five other antitumor drugs in the treatment of advanced (Day 3) L1210 leukemia in (C57BL/6 X DBA/2)F1 mice. The combination of CY with a platinum compound yielded a collective cure rate of 24%; the addition of a third drug to the dual regimen increased the collective cure rate to 55%. The most effective drugs when used in combination with platinum compounds plus CY were, in increasing order of efficacy, 5-fluorouracil, hydroxyurea, and methotrexate. No toxic deaths occurred with any regimen at the dose levels used.