Characterisation of serum fibrinogen degradation products using gel chromatography and radioimmunoassay
Ratky, S.M.; Sykes, A.; Cooke, E.D.; Gordon, Y.B.
Thrombosis and Haemostasis 37(3): 471-476
1977
ISSN/ISBN: 0340-6245 PMID: 578027 Document Number: 111270
Fibrin(ogen) degradation products (FDP) are detected by radioimmunoassay in the serum of all subjects. Some of these FDP have considerable biological activity in vivo, and may play a significant part in the process of coagulation. Chromatography of serum samples from patients including those with pulmonary emboli and deep venous thrombosis indicates that the majority of non-clottable fibrin(ogen)-related antigen present is of high MW.sbd.greater than that of fibrinogen.sbd.and that in pathological situations there is a quantitative increase not a qualitative alteration in the molecular species present.