Mechanism of the anti-inflammatory action of immunodepressants
Zaks, A.S.; Rabotnikov, I.M.; Ovodenko, L.A.; Zil'bermints, L.G.
Farmakologiia i Toksikologiia 40(5): 578-582
1977
ISSN/ISBN: 0014-8318 PMID: 923780 Document Number: 110352
The effectiveness of immunodepressants in lingering exudative processes, their inhibitory action in the proliferative phase of inflammation, depression of the phagocytic activity of leucocytes, as well as suppressive influence on the development of a toxic pulmonary edema and upon generalized anaphylaction reaction was demonstrated in tests staged on rats and mice. The antiphlogistic action of immunodepressants was not abolished during the first hours after their administration by specific metabolites, but was suppressed at the peak of the cytostatic effect together with the latter. The phlogolytic effect was not mediated through the hypophysis-adrenal system and did not include the lienic factor.