Lymphocyte cytotoxicity in X-irradiation-induced adenocarcinoma of the rat small bowel. I. Measurement of target cell destruction by release of radioiodinated membrane proteins: brief communication
Stevens, R.H.; Brooks, G.P.; Osborne, J.W.; Englund, C.W.; White, D.W.
Journal of the National Cancer Institute 59(4): 1315-1319
1977
ISSN/ISBN: 0027-8874 PMID: 904002 Document Number: 110110
A cell-mediated immune response as denoted by lymphocyte cytotoxicity was detected in Holtzman rats with X-irradiation-induced adenocarcinomas of the small bowel. Cytotoxicity was measured by target cell destruction as determined by release of intracellular 51Cr or radioiodinated (125I) membrane proteins. The radioiodination assay possessed an important advantage over the 51Cr technique in that the radiolabel was spontaneously lost slowly, thus permitting long-term studies.