Effect of hydrolyzed formaldehyde-treated RNA on neoplastic and normal human cells
Feldman, M.Y.; Balabanova, H.; Bachrach, U.; Pyshnov, M.
Cancer Research 37(2): 501-506
1977
ISSN/ISBN: 0008-5472 PMID: 556680 Document Number: 110076
Alkaline hydrolysate of dialyzed formaldehyde-treated RNA, in which 39% of purine nucleotides are modified to methylene bis derivatives (R-CH2-R'), displays cytotoxic activity toward cultured human tumor cells. The alkaline hydrolysate of dialyzed formaldehyde-treated RNA is substantially less toxic to normal human embryonic cells. There is a correlation between the cytotoxic effect and cell growth rate, which has been traced by quantitative tests.