Mixed lymphocyte reactions: augmentation by drugs that inhibit stimulator cell protein synthesis
Metzler, C.M.; Kostyk, T.G.; Gershon, R.K.
Journal of Immunology 117(4): 1295-1299
1976
ISSN/ISBN: 0022-1767 PMID: 135808 Document Number: 108838
Inhibiting the protein synthesis of F1 stimulator cells in a mixed lymphocyte reaction (MLR) can enhance the DNA synthetic response and cytotoxic activity of the responder parental lymphocytes, independent of the number of stimulator cells used. Thus stimulator lymphocytes act not only as a source of antigen but play an additional regulatory role in the MLR.
Document emailed within 1 workday
Related Documents
Accolla, R.S.; Moretta, A.; Cerottini, J.C. 1981: Allogeneic mixed lymphocyte reactions in humans: pretreatment of either the stimulator or the responder cell population with monoclonal anti-Ia antibodies leads to an inhibition of cell proliferation Journal of Immunology 127(6): 2438-2442Suthanthiran, M.; Lagman, M.; Rubin, A.L.; Stenzel, K.H.; Novogrodsky, A. 1978: Regulation of human mixed lymphocyte culture reactions: augmentation of proliferation and generation of cytotoxic cells Transplantation Proceedings 10(4): 923-925
Adkinson, N.F.; Rosenberg, S.A.; Terry, W.D. 1974: Early detection of lymphocyte stimulation and mixed lymphocyte interaction in man with a semimicro protein synthesis assay Journal of Immunology 112(4): 1426-1434
Harrison, M.R. 1973: Thymus independent stimulator cells in the mixed lymphocyte reaction Journal of Immunology 111(4): 1270-1273
Mawas, C.; Sasportes, M.; Charmot, D.; Christen, Y.; Dausset, J. 1975: Cell-mediated lympholysis in vitro. Independence of mixed lymphocyte reactions and T-cell mitogen responses from the in vitro generation of cytotoxic effectors in primary immunodeficiency diseases Clinical and Experimental Immunology 20(1): 83-92
Measel, J.W.; Cammarata, P.; Ferguson, K.A.; Distefano, A. 1988: Enhancement of mixed lymphocyte culture reactions between donor and recipient in B cell chronic leukemia using antibody-coated beads Cancer Detection and Prevention 12(1-6): 605-608
Minami, M.; Shreffler, D.C. 1981: Ia-positive stimulator cells are required in primary, but not in secondary, mixed leukocyte reactions against H-2K and H-2D differences Journal of Immunology 126(5): 1774-1779
Nieda, M.; Juji, T.; Imao, S.; Minami, M. 1988: A role of HLA-DQ molecules of stimulator-adherent cells in the regulation of human autologous mixed lymphocyte reaction Journal of Immunology 141(9): 2975-2979
Billiar, T.R.; Curran, R.D.; Stuehr, D.J.; Ferrari, F.K.; Simmons, R.L. 1989: Evidence that activation of Kupffer cells results in production of L-arginine metabolites that release cell-associated iron and inhibit hepatocyte protein synthesis Surgery 106(2): 364-371; Discussion: 371-372
Hämmerling, U.; Toulon, M.; Chun, M.; Palfree, S.; Hoffmann, M.K. 1988: Bidirectionality of mixed lymphocyte stimulation (Mls) response. Effects of Mlsb stimulator cells on Mlsa helper cells Journal of Immunology 140(8): 2543-2548
Payne, J.; Huber, B.T. 1992: Minor lymphocyte stimulatory antigen-bearing stimulator cells require lipopolysaccharide activation to induce programmed cell death in T cell hybridomas Journal of Immunology 149(5): 1571-1576
Nowaczyk, M.; Pluta, A.; Modlińska, M.; Bukowska, J.; Górski, A. 1990: Immunosuppressive drugs inhibit class Ii antigen (HLA-D) synthesis by B and T lymphocytes Archivum Immunologiae et Therapiae Experimentalis 38(5-6): 415-419
Collins, R.C.; Nandi, N.; Smith, C.B.; Sokoloff, L. 1980: Focal seizures inhibit brain protein synthesis Transactions of the American Neurological Association 105: 43-46
Charpentier, B.; Guttmann, R.D.; Shuster, J.; Gold, P. 1977: Augmentation of proliferation of human mixed lymphocyte culture by human alpha-fetoprotein Journal of Immunology 119(3): 897-900
Macphail, S.; Stutman, O. 1987: L3T4+ cytotoxic T lymphocytes specific for class i H-2 antigens are activated in primary mixed lymphocyte reactions Journal of Immunology 139(12): 4007-4015
Knight, S.C.; Burman, S. 1981: Control of mixed lymphocyte reactions by cellular concentration: studies in 20 microliters hanging droplet cultures Transplantation Proceedings 13(3): 1637-1641
Tittor, W. 1977: T-cell subpopulations in mixed lymphocyte cultured. Model of T-cell interactions Fortschritte der Medizin 95(46): 2779; 2781-2784
Puppo, F.; Gurreri, G.; Pattarini, R.; Ranise, A.; Indiveri, F. 1991: Proliferation in autologous mixed lymphocyte reactions, expression of HLA-class Ii antigen and serum immunomodulatory activity in patients with renal insufficiency on chronic dialysis Allergologia et Immunopathologia 19(4): 167-173
Landolfo, S.; Giovarelli, M.; Capusso, A.; Forni, G. 1979: Lymphokine production in primary mixed lymphocyte culture (MLC). III. Alloantigen signals cell-cell interactions involved in migration inhibition factor and immune interferon release Bollettino dell'Istituto Sieroterapico Milanese 58(2): 128-132
Ono, R. 1979: MLTR (mixed lymphocyte tumor cell reaction) Nihon Rinsho. Japanese Journal of Clinical Medicine Suppl: 1581-1582