Immunosuppressive drugs inhibit class Ii antigen (HLA-D) synthesis by B and T lymphocytes
Nowaczyk, M.; Pluta, A.; Modlińska, M.; Bukowska, J.; Górski, A.
Archivum Immunologiae et Therapiae Experimentalis 38(5-6): 415-419
1990
ISSN/ISBN: 0004-069X PMID: 2130806 Document Number: 365426
The influence of immunosuppressive drugs on class II (HLA-D) antigen synthesis and expression by monocytes and B and T cells was studied. The constitutive HLA-D expression on monocytes and malignant B cells was resistant, while the acquisition of those markers by stimulated T cells very sensitive to immunosuppression. Active derivative of cyclophosphamide (4HCy) and cyclosporine proved to be most efficacious inhibitors of class II antigens.
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