Vascular plasmorrhagia in experimental hypertension
Trusov, O.A.; Nanaev, A.K.; Shekhonin, B.V.
Kardiologiia 16(3): 127-129
1976
ISSN/ISBN: 0022-9040 PMID: 1021621 Document Number: 107264
The permeability of the vascular wall to the penetration into it of fibrinogen and serum protein in experimental hypertension of rats (ischemic renal and corticosteroid hypertension) was studied. Use was made of the indirect variant of Coons' method involving application of antisera to the mouse fibrinogen and to serum protein of rats. The development of the study models of experimental hypertension in rats was accompanied by an elevated vascular permeability and insudation of the plasma into the vasal wall. The disruption of the vascular permeability was more pronounced in arterioled of different organs of rats with DOCA-saline hypertension.