Ultrastructure of cells of proper gastric glands and their stroma in hemorrhagic shock in the rat
Roszkiewicz, A.; Roszkiewicz, J.; Lasek, J.
Zeitschrift für Mikroskopisch-Anatomische Forschung 90(6): 1097
1976
ISSN/ISBN: 0044-3107 PMID: 1032440 Document Number: 106538
Ultrastructural changes in the cells of the proper gastric glands and their stroma are biphasic in the hemorrhagic shock. First phase: "paralysis" of the capillary vessels with an oedema of their stroma, an intracellular oedema with hydropic degeneration of the parietal cells and a degranulation of the argentaffin and argentaffin-like cells. Second phase: ischemia of the gastric mucosa with ultrastructural features of: a) the increased secretion of the parietal cells, b) the degranulation of the chief gastric cells, c) the increased secretion processes in the mucous neck cells. These findings suggest that at last 2 factors coincide in the pathogenesis of so-called stress gastric ulcerations: biphasic disturbances of blood circulation initially damage the gastric mucosa and are followed the digestive hyperactivity of the gastric juice finally resulting stress ulceration.