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Heparin-lock maintenance with ten units of sodium heparin in one milliliter of normal saline solution

Hanson, R.L.; Grant, A.M.; Majors, K.R.

Surgery Gynecology and Obstetrics 142(3): 373-376

1976

ISSN/ISBN: 0039-6087
PMID: 1251318
Document Number: 105177
A rapid increase in use of heparin-lock to maintain patency of established intravenous pathways for intermittent and emergency intravenous injections of drugs has given rise to questions concerning the necessary heparin-saline solution concentration to prevent coagulation and minimize or avoid systemic effects of heparin on blood clotting. A series of experimental and clinical studies followed by clinical observations and evaluation have shown that a concentration of 10 U.S.P. units of sodium heparin per milliliter of normal saline solution will maintain patency of heparin-locks without affecting the clotting time, prothrombin time or activated partial thromboplastin time. A procedure of flushing the heparin-lock with 1 milliliter of the recommended heparin-saline solution following each intravenous injection of medication or every eight hours, if medications are not given more frequently, is suggested.

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