Effect of the hepatocarcinogen ethionine on hepatic messenger RNA synthesis
Ashbourne, J.F.; Schultz, G.A.; Forrester, P.I.; Hancock, R.L.
Physiological Chemistry and Physics 8(4): 303-307
1976
ISSN/ISBN: 0031-9325 PMID: 1019256 Document Number: 103715
An experiment was conducted to determine if any changes resulted in the proportion of hepatic messenger RNA following treatment with ethionine, a hepatocarcinogen. The relative specific activity of the total RNA isolated from nontumor-like tissues was increased in Sprague-Dawley rats fed ethionine. However, the percentage of total RNA that was message was found to be decreased in the ethionine-treated rats.
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