Changes in phosphorus metabolism during the tumor growth inhibition by metabolic acidosis
Anghileri, L.J.; Heidbreder, M.
International Journal of Clinical Pharmacology and Biopharmacy 14(1): 1-5
1976
ISSN/ISBN: 0340-0026 PMID: 977199 Document Number: 102756
Ammonium chloride-induced metabolic acidosis produces an increase of the phosphorus turnover rate in tumor tissue. The lower blood protein-bound 32P seems to indicate that the high phospholipid turnover observed in tumor may be related to an increased molecular degradation. It seems likely that this phenomenon together with the augmented release of phospholipid-bound calcium may induce important changes in the cell membrane behavior.