Inhibition of tumor growth by interleukin 10 gene transfer in B16 (F10) melanoma cells
Walos, S.; Szary, J.; Szala, S.
Acta Biochimica Polonica 46(4): 967-970
1999
ISSN/ISBN: 0001-527X PMID: 10824866 Document Number: 511593
Interleukin 10 (IL-10) is a potent immunosuppressive cytokine with an antitumor activity. The effect of IL-10 on tumor growth was tested in murine melanoma cells manipulated by gene transfer to secrete IL-10. In mice bearing B16(F10) tumors expressing IL-10 tumor growth was decreased depending on the amount of secreted IL-10.
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