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Growth inhibition of mouse skin tumor by serine protease inhibitor ONO-3403

Ohkoshi, M.; Okuda, S.

Anticancer Research 21(3b): 1803-1808

2001

ISSN/ISBN: 0250-7005
PMID: 11497262
Document Number: 540005
The new serine protease inhibitor, ONO-3403 is an analog of FOY-305 (Foypan(R)). The IC50s values of ONO-3403 toward serine proteases, such as trypsin, plasmin, kallikrein and thrombin are much lower than that of FOY-305. To investigate the growth-suppressing effect of ONO-3403 on 3-methyl-cholanthrene-induced autochthonous solid tumors in mice, ONO-3403 was intraperitoneally administered to mice at a dose of 4 mg/kg twice a day for 5 weeks. All seven mice receiving the drug had a solitary tumor and showed potent growth suppression (p < 0.001) without any apparent side effects such as hair loss and body weight loss. The results suggest that ONO-3403 may be useful for the treatment of squamous cell carcinoma.

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