Immunologic competence of T- and B-lymphocytes in tolerance induced by cyclophosphamide
Fontalin, L.N.; Novikova, T.K.; Kondrat'eva, I.A.; Pevnitskiĭ, L.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 81(4): 445-447
1976
ISSN/ISBN: 0365-9615 PMID: 1084175 Document Number: 102744
A study was made of immunological competence of T- and B-lymphocytes of mice subjected to tolerogenic treatment (administration of a massive dose of sheep erythrocytes and cyclophosphamide 7 days before the experiment). The capacity of lymphocytes of tolerant mice to influence the interaction of normal T- and B-lymphocytes was also investigated. This form of tolerance was caused not by T-suppressors, but by a true deficiency of T-cells-helpers (both in the thymus and in the spleen), and partially of B-cells (in the spleen). Some lack of B-cells in the bone marrow was connected with a nonspecific action of cyclophosphamide. Cyclophosphamide is supposed to selectively eliminate cells proliferating in response to the antigen.