Increased lung compliance in mice exposed to sulfur dioxide
Weiss, K.D.; Weiss, H.S.
Research Communications in Chemical Pathology and Pharmacology 13(1): 133-136
1976
ISSN/ISBN: 0034-5164 PMID: 1257595 Document Number: 102535
Mice exposed 6-9 days to 40 ppm. SO2 lost 21% of body weight, but static lung compliance increased 37% (P less than or equal to 0.01). Slopes of saline volume-pressure curves increased 8% (non-sig) pointing to a decrease in surface tension rather than tissue elasticity. Alveolar stability, lung weight and lung wet/dry ratio decreased 2 to 6%, whereas trapped gas in-increased 17%, but none were statistically significant.