Airway responses to sulfur dioxide and methacholine in asthmatics
Witek, T.J.; Schachter, E.N.
Journal of Occupational Medicine. Official Publication of the Industrial Medical Association 27(4): 265-268
1985
ISSN/ISBN: 0096-1736 PMID: 3998877 Document Number: 242023
Sulfur dioxide (SO2) is a common air pollutant found in the workplace. Considerable variation exists in the airway responses of asthmatics to the inhalation of SO2. To determine if such variation among asthmatics is related to nonspecific airway reactivity, we compared the threshold doses of methacholine and SO2 required to produce significant changes in flow rates at 60% of the vital capacity below total lung capacity on the partial expiratory flow volume curve in a group of eight mildly asthmatic subjects. A significant correlation between the dose of SO2 and the dose of methacholine required to produce bronchoconstriction (r = .86, p less than .05) was observed, suggesting that there is a relationship between the response to SO2 and the response to methacholine in mildly asthmatic individuals. More generally, nonspecific airway hyperreactivity may help to predict untoward airway responses to inhaled SO2 in the workplace.