Effect of sodium dichloroacetate on hyperlactatemia and hyperpyruvicemia induced by phenformin in the dog
Loubatières, A.L.; Valette, G.; Ribes, G.; Rondot, A.M.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 170(4): 820-824
1976
ISSN/ISBN: 0037-9026 PMID: 11875 Document Number: 102139
In the normal anesthetized dog a continuous perfusion of sodium dichloroacetate (30 mg/kg.h) prevents the increase in blood lactates and pyruvates as well as the lowering of the arterial pH induced by the intraduodenal administration of phenformin (30 mg/kg). Furthermore a perfusion of sodium dichloroacetate (7.5 mg/kg.mn) during 20 minutes, three hours after the administration of phenformin, tends to improve the utilization of blood lactates and pyruvates.