Changes of arterial pressure and biosynthesis of corticosteroids in rats with neurogenic stress
Bankova, V.V.; Kucherenko, A.G.; Markov, K.M.
Kardiologiia 16(9): 127-129
1976
ISSN/ISBN: 0022-9040 PMID: 1034851 Document Number: 102138
By way of a psychogenic stimulation (crowding for 1, 7 and 15 days) neurogenic hypertension was induced in male rats that developed in them within 11-15 days of stress. The biosynthesis of aldosterone, corticosterone, 11-dehydrocorticosterone and desoxycorticosterone by the adrenal glands of the rats in vitro from 14C progesterone greatly increased on the 1st day of stress. In 7 days of the beginning of stress the production of labeled corticosteroids fell to control values (with the exception of 11-dehydrocorticosterone whose production was growing still further). By the 15th day of stress reduction of the biosynthesis of aldosterone, corticosterone and desoxycorticosterone was observed, as well as normalization of the biosynthesis of 11-dehydrocorticosterone.