Effects of prostaglandins in canine endotoxin shock
Shatney, C.H.; Lillehei, R.C.
Acta Biologica et Medica Germanica 35(8-9): 1141-1149
1976
ISSN/ISBN: 0001-5318 PMID: 1007762 Document Number: 101818
Endotoxin shock was produced in healthy, adult mongrel dogs by the intravenous injection of 1.5 mg/kg of E. coli endotoxin. The 24 hour survival of untreated animals was 34% and was not enhanced by volume replacement with low molecular weight dextran. Treatment with dextran and prostaglandin A1 or E1, although effecting significant hemodynamic improvements, did not increase survival.
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