The recent advances in classic BCR-ABL-negative myeloproliferative disorders
Tefferi, A.
Clinical Advances in Hematology and Oncology H&o 5(2): 113-115
2007
ISSN/ISBN: 1543-0790 PMID: 17344799 Document Number: 10165
A large, international quality-of-life (QOL) study was published in the January 1, 2007, issue of Cancer, which reported on 1,179 patients with MPDs. The study found fatigue as a major QOL issue in patients with all three disorders. Other complications affecting QOL included pruritus, night sweats, bone pain, fever, and weight loss. Not surprisingly, the incidence and severity of these constitutional symptoms was the highest in patients with PMF. Interestingly, however, fatigue was self-reported as a major complaint in 85% of PV patients and 72% of those with ET. Another major situation that affects QOL in PMF is the need for frequent red blood cell transfusions. Therefore, treatment that alleviates anemia in PMF has major benefit for patients even if it does not improve survival.
Document emailed within 1 workday
