Pyoderma gangrenosum and myeloproliferative disorders. Report of a case and review of the literature
Romano, J.; Safai, B.
Archives of Internal Medicine 139(8): 932-934
1979
ISSN/ISBN: 0003-9926 PMID: 288320 Document Number: 144102
The exact mechanism involved in the pathogenesis of pyoderma gangrenosum (PG) still remains unclear, yet there is an increasing number of reports associating PG with immunologic abnormalities. A correlation between PG and myeloproliferative disorders has also been described. We describe a patient with chronic myelocytic leukemia in whom PG developed during the course of illness. We present an immunologic analysis of this case, speculation on the pathogenesis of PG, and a review of the literature. We report the futility of current therapeutic modalities in the treatment of PG.