Evaluation of antibrucellic vaccines in mice
Valette, L.; Stellmann, C.
Developments in Biological Standardization 31: 308-313
1976
ISSN/ISBN: 0301-5149 PMID: 816687 Document Number: 101179
The activity of the antibrucellic vaccines was tested on mice by vaccination at varying doses. The vaccinated mice and the controls were then challenged with a fixed quantity of virulent brucella. The animals were then sacrificed, the spleens were weighed and a count was taken of the virulent brucella which they contained. These two indications, weight of the spleen and intensity of infection, allow to compare the activity of the vaccines and to have an indispensible routine test for production control.