Discovery of the hypotensive effect of propranolol
Gillam, P.M.; Prichard, B.N.
Postgraduate Medical Journal 52 Suppl. 4: 70-75
1976
ISSN/ISBN: 0032-5473 PMID: 9633 Document Number: 100836
Following the observation that pronethalol lowered the blood pressure a similar effect was demonstrated with propranolol. Over a period of years propranolol was demonstrated to produce a fall in blood pressure comparable with other potent drugs with the advantage of good control of the supine blood pressure and with the absence of postural and exercise hypotension. These observations were slow to be accepted, as besides a novel mode of action, most attempts to repeat the work failed to pay enough attention to adequate dosage.