Release of xenotropic type C RNA virus in response to lipopolysaccharide: acitivity of lipid-A portion upon B lymphocytes
Phillips, S.M.; Stephenson, J.R.; Greenberger, J.S.; Lane, P.E.; Aaronson, S.A.
Journal of Immunology 116(4): 1123-1128
1976
ISSN/ISBN: 0022-1767 PMID: 176273 Document Number: 99902
The present studies demonstrate that lipopolysaccharide (LPS) causes the release of endogenous xenotropic type-C RNA virus from BALB/c spleen cells. The evidence suggests that virus release is stimulated by the lipid-A portion of LPS and primarily involves an action of LPS on B lymphocytes. LPS had little or no effect on virus release by T lymphocytes, macrophages, or fibroblasts. These results indicate that the differentiated state of the cell plays an important role in the regulation of endogenous virus release.
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