Studies on Withania ashwagandha. (Part II) : Effect of total extract on cardiovascular system, respiration and skeletal muscle

Malhotra, C.L.; Das, P.K.; Dhalla, N.S.

Indian Journal of Physiology and Pharmacology 4: 49-64

1960


ISSN/ISBN: 0019-5499
PMID: 14420295
Document Number: 9956
It has been reported by Malhotra, Das and Dhalla (1960) that the extract of the roots of W. ashwagandha produces sedation of varying degrees in different species of animals and has a biphasic action on smooth muscles. The present report deals with the actions of total extract of roots of W. ashwagandha on the cardio-vascular system, respiration and skeletal muscle. 1. Effect of 70 percent alcoholic extract of W. ashwagandha roots have been studied on the cardiovascular system and respiration in certain species, viz. dogs, frogs and rabbits. 2. The extract has prolonged hypotensive, bradycardiac and respiratory stimulating actions. 3. The hypotensive effect has been found to by mainly due to ganglion blocking action, but also to a minor degree due to parasympathomimetic like action. 4. The extract has also got a weak sympathomimetic like action on heart, 5. The respiratory stimulation is due to central stimulation. 6. It produces contractions of frog's rectus muscle. 7. The multiple sites of action appear to due to the presence of more than one active chemical constituent.

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Studies on Withania ashwagandha. (Part II): Effect of total extract on cardiovascular system, respiration and skeletal muscle