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Concentration of adenylic nucleotides and respiratory phosphorylation in the mitochondria of rats with transplanted tumors

Morozkina, T.S.; Shapot, V.S.

Biulleten' Eksperimental'noi Biologii i Meditsiny 81(6): 727-729

1976

ISSN/ISBN: 0365-9615
PMID: 953312
Document Number: 99368
A study was made of adenylic mononucleotides, the process of oxydative phosphorylation and ATP-ase activity of hepatic mitochondria of rats with transplantable sarcoma 45 and Walker carcinosarcoma at various stages of tumour growtli. A reduction of the ATP levels observed in the hepatic mitochondria of tumour-bearing rats was caused, on the one hand, by suppression of its formation as a result of a partial uncoupling of the oxidative phosphorylation, and on the other hand - by intensification of its decomposition as a result of increased ATP-ase activity.

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