Assessment of Chromosome 22q11.2 Deletion in Patients with Isolated Cleft Palate: a Systematic Review of Prospective Studies
Panamonta, V.; Wichajarn, K.; Wongswadiwat, Y.; Panamonta, M.; Pradubwong, S.; Chowchuen, B.
Journal of the Medical Association of Thailand 99(Suppl 5): S194-S198
2016
ISSN/ISBN: 0125-2208 PMID: 29906081 Document Number: 9927
The prevalence of 22q11.2 deletion in patients presenting with isolated cleft palate has not been systematically To assess the evidence in the literature for the prevalence of 22q11.2 deletion in patients who were presenting with isolated cleft palate. A systematic literature search was conducted through PubMed between 1992 and June 2016 using Of the six prospective studies reported, 328 patients with isolated cleft palate had been screened with FISH (Fluorescence In Situ Hybridization) test for 22q11.2 deletion. Among the 328 patients, there was one (0.3%) patient with positive FISH test for 22q11.2 deletion. This patient was clinically assessed and did not have an associated malformation or clinically recognized syndrome. The prevalence of 22q11.2 deletion among patients with isolated cleft palate is rather low. Of more than