Fibrinolytic agents: a new approach to the treatment of adult respiratory distress syndrome
Hardaway, R.M.; Harke, H.; Williams, C.H.
Advances in Therapy 11(2): 43-51
1994
ISSN/ISBN: 0741-238X PMID: 10147145 Document Number: 989
Nineteen patients suffering from adult respiratory distress syndrome (ARDS) secondary to trauma or sepsis, or both, failed to respond to treatment with mechanical ventilation with oxygen and positive end-expiratory pressure. On the premise that ARDS may be caused by the microclots of disseminated intravascular coagulation obstructing the pulmonary microcirculation, the patients were treated with either streptokinase or urokinase. Eighteen patients responded with significant improvement in PaO 2 value. No bleeding occurred and clotting parameters remained normal.
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