Glycopeptides from the surgace of human neuroblastoma cells
Glick, M.C.; Schlesinger, H.; Hummeler, K.
Cancer Research 36(12): 4520-4524
1976
ISSN/ISBN: 0008-5472 PMID: 1000497 Document Number: 98779
Glycopeptides suggesting a complex oligosaccharide composition are present on the surface of cells from human neuroblastoma tumors and several cell lines derived from the tumors. The glycopeptides, labeled with radioactive L-fucose, were removed from the cell surface with trypsin, digested with Pronase, and examined by chromatography on Sephadex G-50. Human skin fibroblasts, brain cells, and a fibroblast line derived from neuroblastoma tumor tissue show less complex glycopeptides. Although some differences exist between the cell lines and the primary tumor cells, the similarities between these human tumors and animal tumors examined previously are striking.