Permeability of human chorion laeve to diazepam and meperidine
Seeds, A.E.; Stolee, A.; Eichhorst, B.C.
Obstetrics and Gynecology 47(1): 28-30
1976
ISSN/ISBN: 0029-7844 PMID: 942777 Document Number: 98364
In vitro placental permeability to diazepam (Valium) and meperidine (Demerol) in excess of that measured for antipyrine, suggest that these compounds will diffuse across placental tissue in vivo at a maximal or perfusion-limited rate. Such findings correspond to the high fetal blood levels reported for these substances following maternal administration and indicate that these lipid-soluble analgesics cross this tissue by transcellular as well as extracellular pathways.