In vivo antispasmodic activity of Sulcotidil
Roba, J.; Reuse-Blom, S.; Lambelin, G.
Archives Internationales de Pharmacodynamie et de Therapie 221(1): 54-59
1976
ISSN/ISBN: 0003-9780 PMID: 962430 Document Number: 98076
Suloctidil was tested in vivo for its antispasmodic activity on peripheral and cerebral circulations. In the perfused dog hind limb preperation, suloctidil was found to inhibit after 2 and 5 min, the vasospasm induced by norepinephrine or angiotensin; at equal dose, and at the game time intervals, it was more potent than cinnarizine and papaverine. BaCl(2) induced spasms of the pial arterial of the rabbit were also rapidly alleviated by i.a. suloctidil (3.5 mug/kg or more), in conditions where papaverine and vincamine were inactive.