Bumetanide, a new diuretic active during chronic renal failure
Fries, D.; Beroniade, V.; Coy, J.L.; Delavelle, F.
Pathologie-Biologie 24(6): 435-439
1976
ISSN/ISBN: 0369-8114 PMID: 785349 Document Number: 98011
Bumetanide is a new diuretic, which acts in the ascending limb of Henle's loop. The use of very high doses (5 to 40 mg/24 h) in 32 patients with advanced chronic renal insufficiency gave a clear diuretic effect in half the patients with a creatinine clearance of less than 3 ml/min and in 2/3 of the cases with a creatinine clearance between 3 and 10 ml/min. The efficacy of high doses of bumetanide, as well as their good tolerance shows an action of this new diuretic similar to that of furosemide.