Absorptive-excretory function of isolated dog liver during its perfusion
Rozental', R.L.; Tsimermane, G.I.; Krivulis, D.B.; Sondore, A.A.; Sorokin, I.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 81(4): 405-407
1976
ISSN/ISBN: 0365-9615 PMID: 1276436 Document Number: 97973
Twenty experiments were performed on mongrel dogs. The absorptive and excretory function of the liver in the intact organism and during its isolated perfusion through the portal vein with the use of extracorporeal circulation was studied by means of the bromsulfaline test. The absorptive function of the perfused liver proved to decrease by 50-60 per cent. The rate of bile elimination and plasma clearance was 5-6 times higher at the beginning of the experiment in the intact organism. Later on, the difference in the degree of retention of the hepatic excretory function was reduced. Hypoxia connected with denervation, hepatectomy and the isolated perfusion proper apparently served as the principal cause of reduction of the absorptive-excretory function of the isolated liver.