Measurement of human plasma motilin
Bloom, S.R.; Mitznegg, P.; Bryant, M.G.
Scandinavian Journal of Gastroenterology. Suppl 39: 47-52
1976
ISSN/ISBN: 0085-5928 PMID: 1069363 Document Number: 97846
A specific radioimmunoassay has been developed for human plasma motilin. No cross reaction was seen with other gut hormones and only a single major peak of motilin immunoreactivity was found in plasma and gut extracts after gel chromatography. The motilin content of the human duodenum was 165.7+/-15.9 pmol/g wet weight and jejunum 37.5+/-2.8 pmol/g with negligible amounts in the rest of the gut. Fasting plasma motilin concentrations in 100 healthy subjects ranged from less than 5 to 300 pmol/l (mean 72 pmol/l).
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