Effect of 13-Nle-motilin in postoperative ileus patients: a double-blind trial
Ruppin, H.; Kirndörfer, D.; Domschke, S.; Domschke, W.; Schwemmle, K.; Wünsch, E.; Demling, L.
Scandinavian Journal of Gastroenterology. Suppl 39: 89-92
1976
ISSN/ISBN: 0085-5928 PMID: 792985 Document Number: 97487
In this study, the effect of 13-norleucine motilin (13-Nle-M) on post-cholecystectomy ileus was assessed in 6 female patients. 13-Nle-M given by continuous i.v. infusion (0.4 mug/kg-h) on the second and third day following surgery did not influence the manifestation and duration of intestinal paralysis in comparison to 6 control patients treated with 0.9% saline. Bowel sounds, however, were more pronounced in the 13-Nle-M-group. Blood pressure and pulse rate were not influenced by the polypeptide, and no other side effects were seen, either.
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