Histamine-H2-receptor antagonists. Physiological and clinical aspects
Domschke, W.; Domschke, S.
Fortschritte der Medizin 94(18): 1082-1084
1976
ISSN/ISBN: 0015-8178 PMID: 964868 Document Number: 97385
Histamine-H2-receptor antagonists (Burimamide, Metiamide, Cimetidine) may inhibit histamine-stimulated gastric secretion in various species including man; in constrast, conventional antihistaminics (H1-antagonists) do not do so. Gastric secretion as stimulated by pentagastrin, insulin, 2-deoxy-glucose or an intragastrically instilled meal is also decreased by H2-antagonists, and a final common mediator role for histamine in the gastric secretory is discussed. H2-antagonists do also inhibit pancreatic enzyme secretion, but do not affect at all bicarbonate secretion. Recent clinical trials have shown Metiamide to be superior to placebo in therapy of duodenal ulcer.